A new meta-analysis of more than 135,000 people with major depression and more than 344,000 controls has identified 44 genomic variants, or loci, that have a statistically significant association with depression.
Of these 44 loci, 30 are newly discovered while 14 had been identified in previous studies. In addition, the study identified 153 significant genes, and found that major depression shared six loci that are also associated with schizophrenia.
Results from the multinational, genome-wide association study were published April 26 in Nature Genetics.
The study was an unprecedented global effort by over 200 scientists who work with the Psychiatric Genomics Consortium. Co-leaders of the study are Patrick F. Sullivan, Yeargen Distinguished Professor of Psychiatry and Genetics and director of the Center for Psychiatric Genomics at the University of North Carolina at Chapel Hill School of Medicine; and Naomi Wray, professorial research fellow at the University of Queensland in Australia.
“This study is a game-changer,” Sullivan said. “Figuring out the genetic basis of major depression has been really hard. A huge number of researchers across the world collaborated to make this paper, and we now have a deeper look than ever before into the basis of this awful and impairing human malady. With more work, we should be able to develop tools important for treatment and even prevention of major depression.”
“We show that we all carry genetic variants for depression, but those with a higher burden are more susceptible,” Wray said. “We know that many life experiences also contribute to risk of depression, but identifying the genetic factors opens new doors for research into the biological drivers.”
“This pioneering study is incredibly important, for two reasons,” said Josh Gordon, director of the U.S. National Institute of Mental Health. Gordon was not an author on this paper.
“First, it reaffirms the value of large-scale collaborations, particularly in identifying the complex genetics underlying psychiatric illness. Second, it confirms the genetic roots for depression, offering important biological clues that we hope will lead to new and better treatments.”
Read more on the School of Medicine website.